A COMPREHENSIVE STUDY - VAGINAL MICROBIOTA AND IT’S LINK TO PREGNANCY OUTCOMES

Abstract

Pregnancy outcomes are highly associated with the vaginal microbiome, which is essential for preserving reproductive health. This microbial community, which is primarily made up of Lactobacillus species in healthy people, produces lactic acid, hydrogen peroxide, and other antimicrobial substances that prevent the formation of harmful microbes and help to maintain an acidic vaginal environment. Negative pregnancy outcomes, such as preterm birth, miscarriage, and infections like bacterial vaginosis (BV), have been linked to dysbiosis, or an imbalance in the vaginal microbiota. New research emphasizes how important particular microbial patterns, immunological reactions, and metabolic interactions are in determining the course of pregnancy. Our understanding of these intricate interactions is being improved by developments in metabolomic profiling and sequencing technology, opening the door to new preventative, therapeutic, and diagnostic approaches that will maximize the health of mothers and newborns. To improve pregnancy outcomes globally, more research is needed to identify causal relationships and create therapies that target the microbiome.

DOI - https://doi.org/10.65525/SVUP.9788198800473.2025.162-181