Role of Staphylococcus aureus in skin and soft tissue infection

Abstract

Staphylococcus aureus is a Gram-positive, facultative anaerobic bacteria that penetrates human skin and soft tissues. Skin and soft tissue infections (SSTI) triggered by Staphylococcus aureus are growing increasingly prevalent globally, in hospitals moreover, the community. Methicillin-resistant Staphylococcus aureus (MRSA) infections are widely reported in hospital and community contexts, and they might also consist of additional pathogenic bacteria and fungi. S. aureus generates almost one-third of severe bacterial skin and tissue infections, especially methicillin-resistant Staphylococcus aureus (MRSA). Its ability to remain in the skin, either commensally or during an infectious phase, is greatly affected by its cellular structural makeup and population diversity. It causes tissue infection when the skin or mucosal membranes are compromised, resulting in numerous illnesses such as boils, tumors, and cysts. SSTI can range from minor epidermal infections to life-threatening necrotizing fasciitis. S. aureus was sensitive to most of antibiotics, including Tetracycline, penicillin, ciprofloxacin, doxycycline, and azithromycin, Clindamycin, and chloramphenicol. This study focuses on the mechanism of this bacterium in the context of infection and available treatment options.

DOI - https://doi.org/10.65525/SVUP.9788198471956.2025.181-189